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Bibliographic information
Title
|
Lipid Mediators and Their Metabolism in the Brain
|
Authors
|
Akhlaq A. Farooqui
|
Edition
|
-
|
Publisher
|
Springe, 2011
|
ISBN
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144199940X, 9781441999405
|
Length
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351 pages
|
Subjects
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Medical › Neurology
Medical / Neurology
Medical / Neuroscience |
Book Description
Lipid mediators are chemical
messengers that are formed in response to cell stimulation or injury from
membrane phospholipids, sphingolipid, and cholesterol. They play important
roles in internal and external communication and modulate cellular responses
such as the growth arrest, differentiation, adhesion, and migration. Lipid
mediators of arachidonic acid (ARA) metabolism include prostaglandins,
leukotrienes, thromboxanes, lipoxins, whereas lipid mediators of
docosahexaenoic acid (DHA) metabolism are resolvins, protectins,
neuroprotectins, and maresins. The non-enzymic lipid mediators of ARA and DHA
metabolism include isoprostanes, neuroprostanes, isoketals, neuroketals,
isofurans, neurofurans, 4-hydroxynonenal, and 4-hydroxyhexanal. Ceramide,
ceramide 1-phosphate, sphingosine, and sphingosine 1-phosphate are lipid
mediators of sphingolipid metabolism. These mediators are closely associated
with apoptotic cell death, cell proliferation, cell migration, and survival.
Cholesterol-derived mediators include 24-hydroxycholesterol,
25-hydroxycholesterol, 27-hydroxycholesterol, and 22-hydroxycholesterol. These
mediators act as ligands of liver X receptors, transcription factors with key
roles in lipid metabolism. Under normal conditions, low levels of lipid
mediators are needed for signal transduction, gene expression, and neural cell
proliferation and differentiation, but high levels of enzymic and non-enzymic
lipid mediators of glycerophospholipid, sphingolipid, and cholesterol
metabolism produce neurodegeneration through the induction of oxidative stress,
neuroinflammation and synaptic dysfunction.
Lipid Mediators and Their
Metabolism in the Brain presents readers with cutting edge and
comprehensive information not only on the synthesis and degradation of
glycerophospholipid-, sphingolipid-, and cholesterol-derived lipid mediators,
but also their involvement in neurological disorders. It is hoped that this
monograph will be useful not only to postgraduate student and their teachers,
but also to research scientists and physicians, who are curious about the generation
and roles of lipid mediators in the brain.
About the Author
Dr. Akhlaq A. Farooqui is a leader in the field
of signal transduction, brain phospholipases A2, bioactive ether
lipid metabolism, polyunsaturated fatty acid metabolism, glycerophospholipid-,
sphingolipid-, and cholesterol-derived lipid mediators, and glutamate-induced
neurotoxicity.
Dr. Farooqui has authored six monographs: Glycerophospholipids
in Brain: Phospholipase A2 in Neurological Disorders
(2007); Neurochemical Aspects of Excitotoxicity (2008); Metabolism and
Functions of Bioactive Ether Lipids in Brain (2008); and Hot Topics in Neural
Membrane Lipidology (2009); Beneficial Effects of Fish Oil in Human
Brain (2009); and Neurochemical Aspects of Neurotraumatic and Neurodegenerative
Diseases (2010). All monographs are published by Springer, New York. In
addition, Dr. Akhlaq A. Farooqui has edited 4 books (Biogenic Amines:
Pharmacological, Neurochemical and Molecular Aspects in the CNS (2010) Nova
Science Publisher, Hauppauge, N.Y, Molecular Aspects of Neurodegeneration and
Neuroprotection, Bentham Science Publishers Ltd (2011); Phytotherapeutics
and Human Health: Molecular and pharmacological Aspects, Nova Science
Publisher, Hauppauge, N.Y In Press(2011) and Molecular
Aspects of Oxidative Stress on Cell Signaling in Vertebrates
and Invertebrates, Wiley Blackwell Publishing Company, New York in press,
2011).
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