Title : Genetic Modification of Hematopoietic Stem Cells || Author : Christopher Baum
Language : English || Format : .pdf
Size : 6.4 MB
Bibliographic information
Title
|
Genetic Modification of Hematopoietic Stem Cells - Methods
and Protocols.
|
Authors
|
Christopher Baum
|
Edition
|
illustrated
|
Publisher
|
Humana Press, 2011
|
ISBN
|
1617378666, 9781617378669
|
Length
|
490 pages
|
Subjects
|
Science › Life Sciences › Cell Biology
Medical / Genetics
Science / Life Sciences / Cell Biology
Science / Life Sciences / Molecular Biology
|
Book Description
- Provides an easily accessible reference volume for genetic modification of hematopoietic cells using various state-of-the-art vector systems
- Comprehensive guide on functional, phenotypic and genotypic screening of gene-modified cells written by leading researchers in the field
- Contains helpful insights into preclinical data acquisition and documentation for gene therapy, including regulatory comments from the EU and US perspectives
- Covers a wide range of cell-based and animal assay formats and systems
With the incredible potential of gene transfer into
hematopoietic stem cells, active research in this field has become critically
important. In Genetic Modification of Hematopoietic Stem Cells: Methods
and Protocols, leading scientists in the field provide a compendium of
protocols which cover the subject comprehensively, from the purification and
culture of various types of hematopoietic cells for subsequent genetic
modification by vector development and technical issues of small and large
scale vector production, to the complex issue of monitoring and biosafety
studies related to gene-modified hematopoiesis. Written in the highly
successfulMethods in Molecular Biology™ series format, the chapters
in this volume present brief introductions to the topic, lists of the necessary
materials and reagents, step-by-step, readily reproducible laboratory
protocols, and Notes sections, which allow the experts to highlight tips
on troubleshooting and avoiding known pitfalls.
Unique and cutting-edge, Genetic Modification of Hematopoietic
Stem Cells: Methods and Protocols is an ideal, thorough resource to
promote further research and the implementation of investigator-driven clinical
studies using gene-modified hematopoietic cells.
About the Author
-.
Editorial Reviews
"This book provides a unique and comprehensive resource of protocols for the genetic modification of various hematopoietic cell types and up-to-date procedures for molecular and systemic monitoring. … This book is a great help for the design of excellent research in basic hematology, oncology, genetics, and immunology, and also promote the implementation of investigator-driven clinical studies using gene-modified hematopoietic cells. The book represents an outstanding work, which should not be missed in all biomedical research laboratories dealing with gene therapy of hematopoietic cells."
--C. Altaner, Neoplasma, June, 2009
"Haematopoietic stem cells are attractive targets for gene therapy. … Each chapter provides a brief review of the area, followed by a step-by-step guide to undertaking experiments and includes details of reagents required and a list of useful notes or comments of issues that may arise. Comprehensive reference citations provide sources of further information when required. The book should provide a road map for researchers, clinical investigators and regulators involved in modifying haematopoietic cells."
--Waseem Qasim, Human Genetics, Vol. 128, May, 2010
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